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Biosite Inc.

Triage® Cardiac Panel: Rapid Rule-Out of Acute Myocardial Infarction

Chief Complaint:
Left-sided chest pain

Present Illness:
A 58-year-old man presented to the emergency department with complaints of left-sided chest pain while painting, starting yesterday. The pain was severe 7/10 (scale 1-10). Patient medicated self with one nitroglycerin tablet without relief. Patient states pain subsided after two more tablets of nitroglycerin were taken. This morning patient claims that 5/10 left-sided chest pain returned while taking a shower. Patient admits to taking one nitroglycerin tablet that relieved pain to 2/10. Patient denies shortness of breath, nausea or vomiting, or radiation of pain with either episode.

Past Medical History:

  • CAD
  • Hypercholesterolemia
  • Emphysema for past 8 years
  • MI in 1998
  • Denies alcohol abuse
  • Smoking: one pack per day for approximately 40 years

Emergency Department Assessment:

  • Physical Exam
    Temperature: 98.4 Pulse: 82
    Blood Pressure: 110/74 Weight: 185
    O2 Saturation: 96% Height: 5’11”
    General: Alert and oriented
    Chest: Wheezes on inspiration
    Cardiovascular: Normal sinus rhythm, no murmur, no extremity edema
    Neurological: Denies dizziness or blurred vision
    Medications given in the emergency department: O2 , ASA, nitroglycerin sublingual x 1 with chest pain relieved, IV heparin

Initial Labs and Studies:
ECG: Normal sinus rhythm, no ST or T wave changes, Q waves noted in leads II, III, and AVF (indicating old MI). Serial ECGS continued with no S or T wave abnormalities seen.
Chest X-ray: Cardiomegaly (enlarged heart)
Labs: Chemistry panel and CBC unremarkable

CARDIAC MARKER TESTING
Traditional Algorithm vs Accelerated Protocol
TIME CK-MB
(10 ng/mL cutoff*)
Myoglobin
(170 ng/mL cutoff*)
Troponin I
(0.6 ng/mL cutoff*)
Initial Diagnosis and Triaging Decisions
    Traditional
Algorithm
Accelerated
Protocol
Traditional
Algorithm
Accelerated
Protocol
Traditional
Algorithm
Accelerated
Protocol
Traditional
Algorithm
Accelerated
Protocol
Baseline 1.9 - < 0.6 Strong suspicion for possible UA
45 Minutes - - - Patient was sent to CCU within 3 hours
90 Minutes - - -
3 Hours - - - Patient was ruled out after 12-hour marker testing
6 Hours 2.2 - < 0.6
12 Hours 2.6 - < 0.6

* Cutoffs are reflective of reference ranges determined by hospital.

Click here to see how the accelerated protocol could have impact the triaging & disposition of this patient