HOME
PRODUCTS
TRIAGE SYSTEM
CARDIAC PANEL
BNP TEST
PROFILER SHORTNESS OF BREATH PANEL
D-DIMER TEST
D-dimer
PE and DVT
DIC
Product Info
Suggested Reading
Ordering Info
Request Info
Customer Service
FAQs
Resources
TOX DRUG SCREEN
DRUGS OF ABUSE PANEL
C. difficile PANEL
PARASITE PANEL
REIMBURSEMENT
Biosite Inc.

Triage® D-Dimer Test: Product Info

Aids in the assessment and evaluation of patients suspected of having disseminated intravascular coagulation (DIC) and thromboembolic events including pulmonary embolism (PE) and deep venous thrombosis (DVT).

  • Uses highly sensitive, quantitative immunoassay technology.1
  • Utilizes the 3B6 D-dimer antibody, which has demonstrated high clinical specificity for PE and DVT.2,3
  • Correlates with ELISA and other immunoassay methods.1,5
  • Delivers quantitative results in approximately 15 minutes in the lab or at the point-of-care.
  • Performed on the Triage Meters; the Triage System is widely adopted by over 3,500 hospitals worldwide.

The Immunoassay Technology Advantage

The Triage D-Dimer Test is a fluorescence immunoassay that quickly provides accurate, quantitative D-dimer results.

  • D-dimer assays are known to have varied sensitivity for detecting D-dimer.2,3
  • Enzyme-linked immunosorbent assays (ELISA) are known for their high sensitivity in patients with suspected PE and DVT.4
  • ELISA assays are distinguishable from latex agglutination tests due to the presence of capture and detection antibodies, forming a sandwich immunoassay, yielding higher sensitivity.3
  • The Triage D-Dimer Test uses highly sensitive sandwich immunoassay technology to capture and detect D-dimer.1
  • The Triage D-Dimer Test, a fluorescent immunoassay (FIA), directly measures the fluorescent signal that is proportionate to the analyte present in the sample.1

Lateral Flow Sandwich Immunoassay

3B6 Antibody

Measurement of D-dimer is useful in evaluating patients suspected of PE, DVT and DIC, yet not all D-dimer tests are able to detect D-dimer the same way.

  • Antibody specificity plays a significant role in distinguishing D-dimer from other Fibrin Degradation Products (FDPs).2
  • The Triage D-Dimer Test utilizes the 3B6 monoclonal antibody that is highly specific to cross-linked D-dimer.1,2,3

The ability to distinguish D-dimer from other FDPs, is achieved with the 3B6 antibody, which detects the cross-linked epitope of D-dimer.
Plasmin derived FDPs may be detected
in addition to D-dimer, resulting in an
erroneously elevated result		 The 3B6 antibody detects only
cross-linked FDPs (D-dimer) for accurate
measurement of the sample

The Performance You Expect

The Triage D-Dimer Test has a correlation coefficient of 0.92 (r value) to the Stratus CS® D-dimer method (Passing-Bablok regression).1.

    
Slope Intercept ng/mL Correlation Coefficient
0.999 -85.89 r = 0.92



    
Slope Intercept ng/mL Correlation Coefficient
1.330 -204.36 r = 0.962

Per this analysis, a 400 ng/ml upper limit of normal for the Triage D-Dimer Test compares favorably with the VIDAS D-dimer assay cut-off of 500 ng/mL.5

The Utility and Speed You Need

The Triage D-Dimer Test

  • Aids in the assessment and evaluation of patients suspected of having DIC and thromboembolic events including PE and DVT.
  • Provides critical results quickly to clinicians
    • Uses whole blood; eliminating centrifugation time
    • Delivers results in approximately 15 minutes using the Triage Meters
  • Designed for the point-of-care, yet aids in laboratory testing compliance
    • Easy to use
    • Does not require reagent reconstitution
    • Uses multiple on-board controls in the meter, software and Test Device to ensure acceptable performance

The Triage D-Dimer Test

  • Uses highly sensitive immunoassay technology and the highly specific 3B6 antibody for D-dimer2,3
  • Correlates with the VIDAS ELISA D-dimer and other immunoassay systems1,5
  • Aids in the assessment and evaluation of patients suspected of having DIC and thromboembolic events including PE and DVT.
  • Quickly provides lab-quality results in approximately 15 minutes

To learn more about the Triage D-Dimer Test, the Triage System and the entire Biosite® rapid diagnostics portfolio, please call us today at 888-BIOSITE (246-7483), email us at custservice@biosite.com, or send us a Product Information Request.

References

 

 

 

 

3B6 D-dimer The Essential Element™ is a trademark of AGEN® Biomedical LTD

Stratus CS® is a registered trademark of Dade Behring, Inc. Deerfield, IL

VIDAS® D-Dimer is a registered trademark of bioMérieux, Inc., Hazelwood, MO